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In more severe cases, 25 mg P. After 1 to 2 days, dose may be increased 20 to 50 mg daily at semi-weekly intervals. Children age 6 months and older: 0. Adults: 10 to 25 mg P. If no hypotension occurs, 25 to 50 mg I. Intractable bayer schering pharma, acute bayer schering pharma porphyria. Adults: 25 to 50 mg P. For hiccups, if symptoms persist, 25 to 50 mg diluted in 500 to 1,000 ml of normal saline solution and infuse I.

Adults: 25 mg to 50 mg I. Adults: Preoperatively, 25 to 50 mg P. Children age 6 months and older: Preoperatively, 0. Dose may need to be decreased in elderly, debilitated, or emaciated patients. Its most prominent adverse reactions are antimuscarinic and sedative. PharmacokineticsAbsorption: Rate and extent of absorption vary with route of administration. Steady-state serum level is achieved within 4 to 7 days. It may undergo enterohepatic circulation.

Contraindications and precautions Contraindicated in patients hypersensitive to drug and in patients with CNS depression, bone marrow suppression, subcortical damage, or coma.

Antiarrhythmics, disopyramide, procainamide, quinidine: Bayer schering pharma risk of arrhythmias and conduction defects. Anticholinergics: Increases anticholinergic activity and aggravates parkinsonian symptoms. Beta blockers: May inhibit chlorpromazine metabolism, increasing plasma levels and toxicity.

Centrally acting antihypertensives: May bayer schering pharma blood pressure. CNS depressants, parenteral magnesium sulfate: Additive effects are likely. Epinephrine: May cause epinephrine reversal. Lithium: May cause severe neurologic toxicity and decreased response to chlorpromazine.

Propylthiouracil: Increases risk of leflunomide. Sympathomimetics: May decrease stimulatory and pressor effects.

Warfarin: Decreases anticoagulant effect. Monitor INR bayer schering pharma PT. Caffeine: Causes pharmacokinetic alterations and azor therapeutic response. Tell patient to avoid caffeinated foods and beverages.

Alcohol use: Additive effects are likely. Heavy smoking: May reduce response to chlorpromazine.



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